Dynamical modeling of tissue electroporation

A numerical analysis of multicellular environment for modeling tissue electroporation

Simulations probing the conductivity changes of three-dimensional models of biological tissues consisting of random ternary core-shell sphere packings with different spatial scales are described. We investigate the temporal evolution of the electric conductivity of these packings during application of an electric field with magnitude either below or above the value leading to cell membrane elec...

Evaluation of Soft Tissue Sarcoma Tumors Electrical Conductivity Anisotropy Using Diffusion Tensor Imaging for Numerical Modeling on Electroporation

Introduction: There is many ways to assessing the electrical conductivity anisotropyof a tumor. Applying the values of tissue electrical conductivity anisotropyis crucial in numerical modeling of the electric and thermal field distribution in electroporationtreatments. This study aims to calculate the tissues electrical conductivityanisotropy in patients with sarcoma tumors using diffusion tens...

Modeling of Microvascular Permeability Changes after Electroporation

Vascular endothelium selectively controls the transport of plasma contents across the blood vessel wall. The principal objective of our preliminary study was to quantify the electroporation-induced increase in permeability of blood vessel wall for macromolecules, which do not normally extravasate from blood into skin interstitium in homeostatic conditions. Our study combines mathematical modeli...

Finite Element Modeling of in Vivo Electroporation

Transgenic maize plants by tissue electroporation.

In this paper, we describe the transformation of regenerable maize tissues by electroporation. In many maize lines, immature zygotic embryos can give rise to embryogenic callus cultures from which plants can be regenerated. Immature zygotic embryos or embryogenic type I calli were wounded either enzymatically or mechanically and subsequently electroporated with a chimeric gene encoding neomycin...